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目的:观察a-细辛脑注射液辅助治疗儿童支气管哮喘急性发作的疗效。方法:将88例患儿随机分为两组,观察组46例,对照组42例。两组均遵循去除病因、控制发作的治疗原则,避免接触过敏原,积极治疗清除感染病灶,去除各种诱发因素,分别予以解痉、化痰、平喘等对症支持综合处理,根据患儿情况采用不同的给药途径,并保持呼吸道通畅,纠正水、电解质及酸碱平衡,若患儿出现紫绀、大汗淋漓等严重情况则给予相应的抢救。观察组在上述治疗基础上加用a-细辛脑注射液0.5mg/(kg.d)加入5%葡萄糖注射液100mL,静脉点滴,每天1次,两组均以7天为1疗程。结果:观察组总有效率明显优于对照组,两组比较有显著性差异(P<0.05),两组在喘息、呼吸困难、胸闷或咳嗽、哮鸣音消失方面,观察组治疗所需时间明显短于对照组,经统计分析有非常显著性差异(P<0.01),观察组的住院天数明显短于对照组,血清中COX-2、IL-8及IgE含量明显低于对照组,经统计学分析有显著性差异(P<0.05)。结论:a-细辛脑注射液联合西药治疗儿童支气管哮喘急性发作疗效令人满意,值得临床推广。
Objective: To observe the efficacy of a-Asarone injection in the treatment of children with acute attack of bronchial asthma. Methods: 88 cases were randomly divided into two groups, 46 cases in observation group and 42 cases in control group. Both groups followed the principle of removing etiology and controlling seizures, avoiding allergens exposure, actively treating the removal of infection and removing various inducing factors. The patients were treated with symptomatic treatment such as antispasmodic, phlegm, and asthma, respectively. According to the situation of children Using different routes of administration, and to maintain airway patency, correct water, electrolyte and acid-base balance, if the child appears cyanosis, sweating and other serious cases are given the appropriate rescue. Observation group in addition to the above treatment with a-Asarone injection 0.5mg / (kg.d) added 5% glucose injection 100mL, intravenous drip once a day, both were 7 days for a course of treatment. Results: The total effective rate of the observation group was significantly better than that of the control group, there was significant difference between the two groups (P <0.05). In the two groups, the time required for the treatment of the patients in the observation group was shortened for wheezing, dyspnea, chest tightness or cough, (P <0.01). The hospitalization days in the observation group were significantly shorter than those in the control group. The levels of COX-2, IL-8 and IgE in the serum were significantly lower than those in the control group Statistical analysis showed significant difference (P <0.05). Conclusion: A-Asarone injection combined with Western medicine in children with acute attack of bronchial asthma is satisfactory, worthy of clinical promotion.