14-3-3蛋白是1967年由Moore等[1]发现的一种酸性蛋白,是广泛存在于几乎所有真核细胞中的一类重要蛋白家族。研究证实σ亚型与肿瘤的发生关系最为密切,14-3-3σ蛋白能阻止异常细胞周期循环和促进细胞分化成熟,所以称作肿瘤抑制因子。14-3-3σ蛋白异常表达与子宫肌瘤的发生相关, 14-3-3 protein is an acidic protein discovered by Moore et al [1] in 1967 and is a kind of important protein family widely found in almost all eukaryotic cells. Study confirmed that σ subtype most closely related to the occurrence of tumors, 14-3-3σ protein can prevent abnormal cell cycle and promote cell differentiation and maturation, so called tumor suppressor. Abnormal expression of 14-3-3σ protein is associated with the occurrence of uterine fibroids,