例 1:男 ,6 4岁 ,因进行性吞咽困难 4个月 ,于 1989年 9月 13日入院。患者于 196 9年始 ,面部、腹股沟、腋窝、乳头等处皮肤变黑、粗糙、瘙痒味觉迟钝。入院查体 :额、腋窝、腹股沟、乳头有对称性分布局限性黑色斑块 ,皮纹增深 ,表面粗糙不平 ,散在针头至豆大褐色丘疹。手掌皮 Example 1: Male, 64 years old, admitted to hospital on September 13, 1989 for dysphagia 4 months. In 196 years, the patient’s face, groin, axilla, nipple, etc. had darker, rougher, itchy itchiness. Admission examination: The frontal, axillary, groin, and nipple are symmetrically distributed with black patches of limited space. The striae are deepened, and the surface is rough and uneven. They are scattered between needles and large brown papules. Palm skin