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本研究用持续24小时胃内pH测定的方法,旨在比较餐前服用雷尼替丁以抑制食物刺激胃酸分泌及传统睡前服用雷尼替丁的药代动力学作用。材料和方法:有十二指肠溃疡病史现临床上已缓解的15例无症状病人(男11、女4,平均年龄48岁)随机接受单盲法的安慰剂(三餐前加睡前一次),或雷尼替丁300 mg夜间服用(加三次餐前安慰剂),或雷尼替丁150 mg一日三次,餐前服用(加睡前安慰剂)。每例患者均以不同顺序接受这三种疗法,两种疗法之间至少相隔7天。初次检查前一周停服抗酸或抑酸药物,实验期间禁用非试验性药物。胃内pH是通过玻璃微电极来测定,每6秒取样一次。三餐时间为18:00、8:00和12:00。每次治疗后都检出24小时平均pH值,pH平
In this study, 24-hour intragastric pH was used to compare ranitidine before meals to inhibit food-stimulated gastric acid secretion and ranitidine pre-natal bedtime pharmacokinetics. MATERIALS AND METHODS: Fifteen asymptomatic patients (male 11, female 4, mean age 48 years) with a history of duodenal ulcer that had been clinically relieved were randomized to a single-blind placebo (three meals before bedtime ) Or ranitidine 300 mg at night (plus three pre-meal placebo), or ranitidine 150 mg three times daily at mealtime (plus placebo at bedtime). Each patient received these three therapies in a different order, with at least 7 days between the two therapies. Stop taking antacids or acid-suppressing drugs the week before the initial examination, and disable non-experimental drugs during the experiment. The intragastric pH is determined by a glass microelectrode, sampled every 6 seconds. Meals are served at 18:00, 12:00 and 12:00. After each treatment are detected 24 hours the average pH, pH level