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[目的]探讨非酒精性脂肪性肝病(NAFLD)患者小肠细菌过度生长(SIBO)的发生率及其临床意义。[方法]46例NAFLD患者根据肝功能情况分为肝功能正常组、肝功能异常组,通过葡萄糖氢呼气试验(GHBT)分别检测其SIBO情况,并与健康对照组进行组间比较分析。[结果]肝功能正常组、肝功能异常组与健康对照组的SIBO阳性率及试餐后呼气氢浓度比较均差异有统计学意义(P<0.01)。肝功能异常组与肝功能正常组的SIBO阳性率及试餐后呼气氢浓度比较差异亦有统计学意义(P<0.05)。[结论]NAFLD患者常存在SIBO,且肝功能异常的NAFLD患者其SIBO发生率更高,但其因果关系尚需阐明。
[Objective] To investigate the incidence of intestinal bacterial overgrowth (SIBO) in patients with non-alcoholic fatty liver disease (NAFLD) and its clinical significance. [Methods] 46 patients with NAFLD were divided into normal liver function group and abnormal liver function group according to the liver function. The SIBO status was detected by GHBT and compared with healthy control group. [Results] The positive rates of SIBO in normal liver function group, abnormal liver function group and healthy control group and the expired hydrogen concentration after test meal were significantly different (P <0.01). The SIBO positive rate of liver dysfunction group and normal liver function group and the difference of postprandial expiratory hydrogen concentration were also statistically significant (P <0.05). [Conclusion] Patients with NAFLD often have SIBO and the incidence of SIBO is higher in patients with NAFLD with abnormal liver function. However, its causal relationship needs to be elucidated.