两性霉素B治疗瘙痒病的机理，1982年美国Prusiner证明羊瘙痒病是一种分子量为3．0×04的蛋白质感染因子引起的并称之为蛋白侵染于或称脱病毒。脱病毒是蛋白质成份而不是核酸。但不久发现这类微生物实际上含有微量核酸，因此命名被否定。Prusiner教授在1993年8月召开的第九届国 Amphotericin B in the treatment of scrapie disease mechanism, the United States in 1982 Prusiner proves scrapie disease is a molecular weight of 3.0 × 04 caused by protein infectious agents and called protein infestation or de-virus. Virus removal is a protein component rather than a nucleic acid. However, it was soon discovered that such microorganisms actually contained trace amounts of nucleic acids, so the nomenclature was negative. Professor Prusiner held its ninth session in August 1993