论文部分内容阅读
２０例肝豆状核变性（ＨＬＤ）患者，男１１例，女９例。年龄１０～３７岁（平均２０±６．４岁）。口服二巯丁二酸（ＤＭＳＡ）７０ｍｇ／ｋｇ．ｄ，观察８周，结果表明：７例显效，１２例好转，１例无效，有效率达９５％。疗前与疗后１～８周２４ｈ尿铜比较，结果显示：疗后各周及疗后总平均尿铜值均显著高于疗前。其尿排铜增高与临床疗效相一致。治疗期６例出现齿龈出血、皮下瘀斑外，未见其他副反应。说明ＤＭＳＡ是治疗ＨＬＤ的一种较理想的驱铜药物。
20 patients with hepatolenticular degeneration (HLD), 11 males and 9 females. Ages 10 to 37 years (average 20 ± 6.4 years). Oral thioglycolic acid (DMSA) 70 mg / kg. d, observed for 8 weeks, the results showed that: 7 cases markedly improved, 12 cases improved, 1 case ineffective, the effective rate was 95%. Urine and copper were compared 24h before and after treatment 1 to 8 weeks, the results showed: after treatment, the average urinary copper in each week and after treatment were significantly higher than before treatment. Urinary copper increased its clinical efficacy consistent. 6 cases of treatment of bleeding gums, subcutaneous ecchymosis, no other side effects. DMSA is an ideal copper-driving drug for the treatment of HLD.