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目的 了解2型糖尿病并发肺结核(type 2 diabetes mellitus complicated with pulmonary tuberculosis,T2DM-PTB)患者血清中炎症细胞因子白细胞介素-12 (interleukin-12,IL-12)、趋化因子配体1(chemokine cytokines ligand 1,CCL1)水平的变化情况.方法 选取2014年9月至2015年6月在黑龙江省传染病防治院就诊的T2DM-PTB患者40例(T2DM-PTB组),T2DM患者40例(T2DM组),以及体检科筛查出的健康人群40名(对照组)作为研究对象.收集研究对象人口学特征资料,并抽清晨空腹静脉血3～4 ml.使用酶联免疫吸附试验检测研究对象血清中IL-12和CCL1的水平,并进行比较.结果 对照组、T2DM组和T2DM-PTB组血清中IL-12水平分别为(9.87±2.75) μg/L、(11.25±1.99) μg/L、(13.33±3.67) μg/L,三组间比较差异有统计学意义(F=4.46,P＜0.01);进一步的两两比较显示,T2DM组和T2DM-PTB组均高于对照组,T2DM-PTB组高于T2DM组,差异均有统计学意义(P值均＜0.05).对照组、T2DM组和T2DM-PTB组血清中CCL1水平分别为(158.03±29.21) μg/L、(245.02±33.04) μg/L、(381.60±29.99) μg/L,三组间比较差异有统计学意义(F=267.90,P＜0.01);进一步的两两比较显示,T2DM组和T2DM-PTB组均高于对照组,T2DM-PTB组高于T2DM组,差异均有统计学意义(LSD检验,P值均＜0.05).结论 T2DM-PTB患者血清中IL-12和CCL1水平明显升高,对T2DM-PTB的发病机制有提示作用.“,”Objective To investigate the relationship between serum levels of interleukin-12 (IL-12),Chemokine cytokines ligand 1 (CCL1) and type 2 diabetes mellitus complicated with tuberculosis (T2DM-PTB).Methods From September 2014 to June 2015 in the Infectious Hospital of Heilongjiang Province,40 cases of T2DM-PTB patients (group T2DM-PTB),40 cases of T2DM patients (group T2DM),and 40 healthy people (control group) were selected as the research objects.The demographic characteristics of the subjects were collected.In addition,3 to 4 ml venous blood was collected in the early morning.The serum levels of IL-12 and CCL1 were measured by enzyme-linked immunosorbent assay and compared among groups.Results The serum concentrations of IL-12 in the control group,T2DM group and T2DM-PTB group were (9.87± 2.75) μg/L,(11.25 ± 1.99) μg/L and (13.33±3.67) μg/L,respectively.The difference among the three groups was significant (F=4.46,P＜ 0.01).The serum levels of CCL1 in the control group,T2DM group and T2DM-PTB group were (158.03 ± 29.21)μg/L,(245.02±33.04) μg/L and (381.60±29.99) μg/L,respectively.The difference among the three groups was significant (F=267.90,P＜0.01).The serum levels of IL-12 and CCL1 in the T2DM and T2DM-PTB groups were significantly higher than that in the healthy control group,and the serum levels of IL-12 and CCL1 in the T2DM-PTB group was significantly higher compared with the T2DM group (P＜0.05).Conclusion The serum levels of IL-12 and CCL1 in patients with T2DM-PTB were significantly increased,suggesting their roles in the pathogenesis of T2DM-PTB.