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目的:探讨诱骗受体3和癌胚抗原与特发性肺间质纤维化的关系。方法:特发性肺间质纤维化患者46例和健康体检者(对照组)30例,采用双抗体夹心酶联免疫法检测血清诱骗受体3水平,间接酶联免疫吸附法检测癌胚抗原水平。结果:与对照组比较,特发性肺间质纤维化组血清诱骗受体3及癌胚抗原水平明显升高(P<0.01),诱骗受体3及癌胚抗原与特发性肺间质纤维化严重程度具有一定相关性。结论:联合监测血清诱骗受体3及癌胚抗原水平,对特发性肺间质纤维化的诊断和判断进展及预后具有参考价值。
Objective: To investigate the relationship between decoy receptor 3, carcinoembryonic antigen and idiopathic pulmonary fibrosis. Methods: Forty-six patients with idiopathic pulmonary fibrosis and 30 healthy volunteers (control group) were enrolled in this study. Serum decoy receptor 3 level was detected by double antibody sandwich enzyme-linked immunosorbent assay (ELISA) and indirect immunosorbent assay Level. Results: Compared with the control group, the levels of serum decoy receptor 3 and carcinoembryonic antigen in idiopathic pulmonary fibrosis group were significantly increased (P <0.01), decoy receptor 3 and carcinoembryonic antigen were associated with idiopathic pulmonary interstitial fibrosis Fibrosis severity has some relevance. Conclusion: The combined monitoring of serum decoy receptor 3 and carcinoembryonic antigen level has reference value for the diagnosis and diagnosis of idiopathic pulmonary fibrosis and its prognosis.