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目的探讨抗菌药物不同使用时机对剖宫产术后感染的影响,为临床抗菌药物的合理使用提供参考依据。方法选取了2010年3月-2013年12月收治的实施剖宫产手术产妇共240例,按照随机的原则将其分为A、B、C组,每组各80例,其中A组产妇在实施剖宫产手术前2h静脉滴入头孢孟多,剂量为1.5g;B组产妇于手术前30min给予同等剂量的头孢孟多酯静脉滴入;C组产妇在手术后的1~2d给予头孢孟多静脉滴注,用药后对3组患者手术愈合、感染等进行统计对比。结果术后感染率A组为5.0%、B组为2.5%、C组为10.0%,3组患者术后感染率比较差异有统计学意义(P<0.05);手术后患者切口愈合以及产褥感染率A、B组均优于C组,而B组产妇在各项感染指标上比较优于A组。结论抗菌药物应用时机对剖宫产术后感染发生有着重要影响,手术前使用抗菌药物的抗感染效果显著好于术后,且以术前30min给药效果最佳,对此需要在临床上引起重视,在合理使用抗菌药物的基础上降低产妇术后感染的发生率。
Objective To investigate the influence of different use timings of antibacterial agents on infection after cesarean section and provide reference for the rational use of antibacterial drugs. Methods A total of 240 maternal women undergoing cesarean section were selected from March 2010 to December 2013. According to the randomized principle, they were divided into groups A, B and C, 80 cases in each group, in which group A maternal Cesarean section was administered intravenously 2 hours prior to cesarean section, and the dose was 1.5g. In group B, the same dose of cefetamet was administered intravenously 30 minutes before operation. In group C, Meng more intravenous infusion, after treatment on the 3 groups of patients with surgical healing, infection and other statistical comparison. Results The postoperative infection rate was 5.0% in group A, 2.5% in group B and 10.0% in group C, and the postoperative infection rates in the three groups were significantly different (P <0.05). The wound healing and puerperal Infection rate A, B group were better than C group, while B group of women in the infection index is better than A group. Conclusion The timing of antimicrobial agents has an important effect on the incidence of post-cesarean section infection. The anti-infective effect of antimicrobial agents before surgery is significantly better than that of postoperative and the optimal effect is given 30 minutes before surgery, which needs to be clinically caused Emphasis on the rational use of antimicrobial agents to reduce the incidence of maternal postoperative infection.