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目的评估葛花解酲汤用于急性乙醇中毒治疗的临床效果。方法将2008年7月至2013年12月急诊就诊的急性乙醇中毒患者120例随机分为两组,每组60例,均常规给予吸氧、高糖、B族维生素、钾镁极化液等基础治疗。对照组(纳洛酮组)予纳洛酮0.8 mg静脉注射,继以1.2 mg纳洛酮加入5%或10%葡萄糖注射液500 ml中静脉滴注;治疗组(纳洛酮+葛花解酲汤组)在对照组基础上给予葛花解酲汤100 ml鼻饲或口服。治疗8 h后观察两组疗效。结果治疗后8 h,治疗组总有效率高于对照组(95.0%vs48.3%),意识恢复时间[(320±76)min vs(1 024±89)min]及平均住院时间[(35.12±9.26)h vs(79.31±14.11)h]均明显少于对照组(P均<0.05)。结论葛花解酲汤鼻饲或口服结合静脉注射纳洛酮较单独静脉注射纳洛酮对急性乙醇中毒治疗效果好,预后佳。
Objective To evaluate the clinical effect of Gehuachao Decoction for the treatment of acute alcoholism. Methods A total of 120 acute alcohol poisoning patients from July 2008 to December 2013 were randomly divided into two groups, 60 cases in each group. All patients were routinely given oxygen, high glucose, B vitamins, Basic treatment. The control group (naloxone group) received intravenous injection of naloxone (0.8 mg), followed by intravenous injection of 1.2 mg naloxone into 500 ml 5% or 10% glucose injection. The treatment group (naloxone +酲 soup group) on the basis of the control group given Ge Hua Xie Tang 100 ml nasal or oral. Eight hours after treatment, the curative effect was observed. Results After 8 h of treatment, the total effective rate in the treatment group was significantly higher than that in the control group (95.0% vs 48.3%), the time to consciousness recovery (320 ± 76) min vs (1024 ± 89) min and the average hospital stay ± 9.26) h vs (79.31 ± 14.11) h] were significantly less than those in the control group (all P <0.05). Conclusion Puerariae soup nasal feeding or oral administration of naloxone intravenously compared with intravenous injection of naloxone on acute alcohol poisoning treatment effect is good, the prognosis is good.