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目的 :探讨P53 基因产物在肾盂癌及癌旁组织表达的意义。方法 :用免疫组织化学方法对 36例肾盂癌及癌旁组织研究 ,并和 7例正常肾盂组织进行对照。结果 :P53 蛋白在肾盂癌中阳性率为 41.7% ,癌旁组织阳性率为 8.3% ;在肾盂癌的病理分期和分级中 ,P53 蛋白的表达强度随分期、分级升高而增强。结论 :P53 蛋白在肾盂癌及癌旁组织阳性表达时预后不良
Objective: To investigate the significance of P53 gene product in renal pelvis and adjacent tissues. Methods: Thirty-six cases of renal pelvic cancer and adjacent non-cancerous tissues were studied by immunohistochemistry and compared with 7 normal renal pelvis tissues. Results: The positive rate of P53 protein in renal pelvic carcinoma was 41.7% and the positive rate of para-cancerous tissue was 8.3%. The expression of P53 protein was increased with the stage and grade of renal pelvis carcinoma in pathological stage and grading. Conclusion: P53 protein is poorly prognostic in renal pelvis and paracancerous tissues