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目的:了解2010-2013年某院报告为严重的药品不良反应的发生情况,促进临床安全合理用药。方法:回顾性调查某院121例严重的不良反应病例报告,从患者的一般情况、药品种类、不良反应类型等方面进行统计和分析。结果:121例严重的不良反应中,男性略多于女性,以≥60岁老年患者居多;怀疑药品以抗感染药物最多,代表药物为头孢哌酮钠舒巴坦钠;涉及药品中注射剂型最多,口服给药方式最常见;累及系统或器官以消化系统居首,其次为全身损害;临床表现以过敏为多。结论:应继续加强临床药品不良反应尤其是严重的药品不良反应的监测,为临床安全合理用药提供依据。
OBJECTIVE: To understand the incidence of adverse drug reactions reported by a hospital from 2010 to 2013 and to promote the safe and rational drug use in clinical practice. Methods: A retrospective survey of 121 cases of serious adverse reactions in a hospital, from the general situation of patients, types of drugs, adverse reaction types and other aspects of statistics and analysis. Results: Of the 121 serious adverse reactions, the male was slightly more than the female, with the majority being older than 60 years of age. The most suspected anti-infective drugs were drugs, which represented the drug cefoperazone sodium and sulbactam sodium. The most common way of medicine; involving the system or organ dominated by the digestive system, followed by systemic damage; clinical manifestations of allergies and more. Conclusion: It is necessary to continue to strengthen the monitoring of adverse reactions of clinical drugs, especially serious adverse drug reactions, and provide the basis for clinical safe and rational drug use.