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加压素(Vasopressin)能减少肠系膜动脉血流从而减少门脉血流,降低门脉压力,故有助于停止因门脉高压引起食管、胃底静脉曲张所致的出血。一般使用加压素以1单位/分的速度快速静滴,20分钟结束。但此法使冠脉血流和心排出量亦明显减少,对心绞痛和心肌梗死病人带来不良影响。选择性肠系膜上动脉插管采用低剂量每分钟0.1～0.3单位加压素注入可有效地控制食管、胃底静脉曲张出血。这种低剂量和选择性局部灌注药物的方法可以减少药物对全身的副作用。但选择性肠系膜上动脉插管较费时,偶尔发生危险,有些病人不能完成。
Vasopressin can reduce the flow of mesenteric artery to reduce portal blood flow, reduce portal pressure, it helps to stop due to portal hypertension caused by esophageal and gastric varices bleeding. General use of vasopressin at 1 unit / min rapid intravenous infusion, 20 minutes to end. However, this method of coronary blood flow and cardiac output also significantly reduced, angina and myocardial infarction patients with adverse effects. Selective mesenteric artery cannulation using low doses of 0.1 to 0.3 units per minute vasopressin injection can effectively control the esophageal and gastric varices bleeding. This low-dose and selective local drug infusion method can reduce the systemic side effects of the drug. However, selective mesenteric artery catheterization is time-consuming, occasionally dangerous, some patients can not be completed.