论文部分内容阅读
目的 :分析免疫学指标对诊断系统性红斑狼疮患者及病情监测的意义。方法 :分别应用单向免疫扩散法、间接免疫荧光法、快速斑点免疫金渗滤法、免疫印迹技术、形态学方法。结果 :活动期IgG、IgA、IgM升高 ,C3、C4 下降ANA抗体、dsDNA抗体及ENA抗体阳性 ,淋巴细胞转化率下降 ;非活动期IgG、IgA、IgM、C3、C4 近似参考值 ,ANA抗体、dsDNA抗体滴度下降或转阴 ,ENA抗体及淋巴细胞转化率无明显变化。结论 :免疫学检查是诊断系统性红斑狼疮重要的指标 ,ANA抗体dsDNA抗体 ,SM抗体是患者血清中的标志抗体。
Objective: To analyze the significance of immunological indexes in the diagnosis of patients with systemic lupus erythematosus and their condition monitoring. Methods: One-way immunodiffusion, indirect immunofluorescence, rapid dot immunogold filtration, immunoblotting and morphological methods were used respectively. Results: The activity of IgG, IgA, IgM increased, C3, C4 decreased ANA antibody, dsDNA antibody and ENA antibody positive lymphocyte transformation rate decreased; inactive IgG, IgA, IgM, C3, C4 approximate reference value, ANA antibody , DsDNA antibody titer decreased or turned negative, ENA antibody and lymphocyte transformation rate did not change significantly. Conclusion: Immunological examination is an important index in the diagnosis of systemic lupus erythematosus. ANA antibody dsDNA antibody and SM antibody are the serum antibody in the patients.