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本研究以大样本病例—对照研究和家族为基础的遗传不平衡试验(ＴＤＴ),研究细胞毒性Ｔ淋巴细胞相关4(ＣＴＬＡ4)基因外显子1中49位的ＡＧ多态性在英国高加索Ｇｒａｖｅｓ病患者中的作用及此多态性的基因型与Ｇｒａｖｅｓ病表现型(甲亢严重程度)的关系。材料与方法 研究对象为
In this study, a large sample of case-control studies and family-based genetic imbalance test (TDT), cytotoxic T lymphocyte-associated 4 (CTLA4) gene exon 1 in AG polymorphism 49 in the British Caucasians The role of the disease and the relationship between the genotype of this polymorphism and the phenotype of Graves disease (hyperthyroidism severity). Materials and methods research object is