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目的慢性萎缩性胃炎是否发生癌变是一个争论的问题．为了研究慢性萎缩性胃炎胃粘膜血管病变的发生与胃癌的关系，应用大鼠进行实验观察胃粘膜的改变．方法应用ＭＮＮＧ（１５０ｍｇ／Ｌ）在诱癌（ｎ＝１５０）过程中动态观察胃粘膜间质组织形态学改变及ＶｉｔＤ３的作用．并用墨汁主动脉灌注以观察粘膜血管的改变．结果局限性血管内皮细胞增大、数量增多是导致粘膜组织有效的血液循环减少，引起粘膜组织萎缩的主要因素．经主动脉灌注墨汁表明粘膜腺体萎缩区血管明显减少，粘膜组织呈现一个功能低落，组织变性消失的过程．结论慢性萎缩性胃炎不是胃癌的直接相关性病变．
Purpose Chronic atrophic gastritis is a matter of debate whether canceration occurs. In order to study the relationship between gastric mucosal vascular lesions and gastric carcinomas in chronic atrophic gastritis, rats were used to observe the changes of gastric mucosa. Methods MNNG (150mg / L) was used to dynamically observe the changes of gastric mucosa interstitial tissue morphology and VitD3 during carcinogenesis (n = 150). And perfused with ink aorta to observe changes of mucosal blood vessels. The results of limitations of vascular endothelial cells increased, an increase in the number of mucosal tissue is caused by an effective reduction of blood circulation, causing mucosal atrophy of the main factors. Perfusion of the aorta ink shows that mucosal atrophy of the vasculature decreased significantly, mucosal tissue showed a low function, the process of tissue degeneration disappeared. Conclusion Chronic atrophic gastritis is not a direct correlation of gastric cancer.