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目的：观察利多卡因对兔注射内毒素２４ｈ后的治疗效应。方法：用日本大耳白兔随机分为对照组、大肠杆菌内毒素（ＥＴ）组和ＥＴ注入后２４ｈ＋利多卡因（ｌｉｄｏｃａｉｎｅ）组。用酶联免疫法和硫代巴比妥酸反应法测量血浆和支气管肺泡灌洗液（ＢＡＬＦ）中ＴＮＦα和ＭＤＡ含量。结果：免静注ＥＴ后２４ｈ再静注利多卡因，于静注利多卡因后３、５ｈ，血浆和ＢＡＬＦ中ＴＮＦα和ＭＤＡ含量显著降低，血中性粒细胞数目明显回升。肺湿干重比值和ＢＡＬＦ中性粒细胞数、白蛋白含量、Ｃ３ａ、Ｃ５ａ浓度无明显变化。结论：内毒素肺损伤后（注ＥＴ后２４ｈ）用ｌｉｄｏｃａｉｎｅ仍可抑制脂质过氧化反应和炎症介质的释放。对肺损伤晚期仍有一定的治疗作用
Objective: To observe the therapeutic effect of lidocaine on endotoxin in rabbits after 24h injection. Methods: Japanese white rabbits were randomly divided into control group, E. coli endotoxin (ET) group and 24h + lidocaine group after ET injection. The levels of TNFα and MDA in plasma and bronchoalveolar lavage fluid (BALF) were measured by enzyme-linked immunosorbent assay and thiobarbituric acid reaction. Results: After intravenous injection of ET, lidocaine was intravenously injected 24h later, and the levels of TNFα and MDA in plasma and BALF were significantly decreased 3 and 5 h after intravenous injection of lidocaine, respectively. The number of blood neutrophils rose significantly. Lung wet dry weight ratio and BALF neutrophil count, albumin content, C3a, C5a concentration no significant change. CONCLUSION: LIPA can inhibit lipid peroxidation and inflammatory mediators release after endotoxin-induced lung injury (24h after ET). Late lung injury still have some therapeutic effect