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鱼藤酮是一种常见的杀虫剂,也是线粒体呼吸链复合体I的特异性抑制剂,大鼠长期喂鱼藤酮可以引起类似帕金森病(PD)的生化和组织水平的改变,如黑质致密部多巴胺能神经元的选择性丧失等等。该文用PC12细胞系从氧化应激的角度论证多巴胺在此细胞毒性过
Rotenone is a common insecticide and is also a specific inhibitor of mitochondrial respiratory chain complex I. Long-term rat rotenone exposure can cause biochemical and tissue-like changes similar to Parkinson’s disease (PD), such as substantia nigra compactness Selective loss of dopaminergic neurons and more. In this paper, PC12 cell line from the perspective of oxidative stress demonstrated that dopamine in this cytotoxicity