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山东省克山病主要分布于鲁中南低山丘陵棕壤与褐土的复合区,化学生态环境为微量元素缺乏区,尤其是元素硒的贫乏是克山病区的共同特征。在同一地点间隔十年的追踪调查表明,近几年来病情减轻的原因与人体硒水平上升有密切关系。1987年与1976年相比,由于病区居民硒摄入量随着膳食构成比例的变化而提高,未服硒地区的人发硒值与服硒点的人发硒值呈同样上升趋势。复合病因研究表明,克山病从环境到人体低Se外,低Mo高Mn、V等元素的不协调,可能起着与低Se复合致病作用。
Keshan disease in Shandong Province is mainly distributed in the composite area of brown soil and cinnamon soil in the hilly area of central and southern Shandong Province, and its chemical and ecological environment is a trace element deficient area. In particular, the deficiency of elemental selenium is a common feature of Keshan ward. Follow-up surveys conducted at the same location for 10 years indicate that the reason for the reduction in recent years is closely related to the increase of human selenium levels. Compared with 1976, the selenium intake of residents in ward increased with the change of dietary composition. The selenium value of human being who did not take selenium was the same as that of selenium in 1987. Complex etiology studies have shown that Keshan disease from the environment to the human body outside the low Se, low Mo high Mn, V and other elements of the uncoordinated, may play a complex role with low Se.