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1983～1989年我们从北京、江苏、辽宁、上海、江西、湖北、安徽、河南等省市收集了3,026株痢疾杆菌和655株大肠杆菌(非侵袭性)菌株,其中310对菌株来自同一病人。监测结果表明,痢疾杆菌和大肠杆菌耐药性均甚严重,且呈持续性,多由耐药性质粒介导。本文提出“痢疾杆菌持续高耐药率与痢疾持续高发病率存在一定的关联,应结合克服耐药性,来考虑和制定痢疾防治规划的建议”,并指出“痢疾杆菌与大肠杆菌间耐药性在生物体内及外环境有相互传递的现象”,对防制耐药性的产生和扩散,对解释药敏结果有时与临床用药效果不符,在小范围内应用大肠杆菌耐药性监测资料能否预测预报痢疾杆菌(或其他肠道菌)耐药性变迁的趋势,均有重要意义。我国痢疾杆菌耐药性质粒不相容性分群有六个群,北方以F②群,南方以 J 群为优势群;此结果对了解多耐菌株增多有所邦助。
From 1983 to 1989, 3,026 strains of Shigella and 655 Escherichia coli (non-invasive) strains were collected from Beijing, Jiangsu, Liaoning, Shanghai, Jiangxi, Hubei, Anhui and Henan provinces, 310 of which were from the same patient. Monitoring results show that Shigella and Escherichia coli resistance are very serious, and was persistent, mostly mediated by the drug-resistant plasmid. This paper proposed that “the continuous high drug resistance rate of Shigella dysenteriae and the persistently high incidence of dysentery are related to each other, and suggestions on planning and controlling dysentery should be considered in combination with overcoming the drug resistance” and pointed out that “the drug resistance between dysentery bacillus and Escherichia coli Sex in the body and the environment outside the mutual transmission of the phenomenon, ”the emergence and spread of the control of drug resistance, the interpretation of drug sensitivity results sometimes inconsistent with the clinical use of drugs, the application of E. coli drug resistance monitoring data in a small area Whether or not to forecast the trend of the change of drug resistance in Shigella dysenteriae (or other intestinal bacteria) is of great significance. There are six groups in China for the incompatibility of Shigella flexneri resistance plasmids, F 群 group in the north and J group in the south as the dominant group. This result is helpful to understand the increase of multi-resistant strains.