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目的了解泉州市结核分枝杆菌(结核杆菌)对利福平的耐药情况以及利福平耐药结核病的流行特征,为制定防控策略提供依据。方法对2012—2015年收集的1068例结核杆菌分离株进行4种一线抗结核药敏试验,并对利福平耐药结核病疫情资料进行分析。结果在1068株结核杆菌分离株中,利福平耐药212株,总耐药率19.9%;初治耐药率7.7%,复治耐药率高达33.1%。利福平耐多药菌株占75.0%(159/212);不同性别、年龄和户籍患者的耐药率差异无统计学意义.结论泉州市利福平耐药结核病的耐药形势不容乐观,应加强对初治病人规范化治疗管理。耐利福平可作为泉州地区耐多药结核病的初筛指标,可根据初筛指标制定合理治疗方案,防止耐多药结核病发生。
Objective To understand the drug resistance of rifampicin to Mycobacterium tuberculosis (TB) in Quanzhou and the epidemiological characteristics of rifampicin-resistant tuberculosis, so as to provide basis for making prevention and control strategies. Methods A total of 1068 Mycobacterium tuberculosis isolates collected from 2012 to 2015 were subjected to four first-line antimicrobial susceptibility tests and the epidemiological data of rifampicin-resistant tuberculosis were analyzed. Results Among 1068 Mycobacterium tuberculosis strains, 212 were resistant to rifampicin, with a total resistance rate of 19.9%. The initial drug resistance rate was 7.7% and the rate of retargeted drug resistance was as high as 33.1%. The rate of multidrug-resistant rifampicin strains was 75.0% (159/212). There was no significant difference in the drug resistance rates among patients of different sex, age and household registration.Conclusion The resistant situation of rifampicin-resistant tuberculosis in Quanzhou is not optimistic Strengthen the standardization of treatment of patients with initial management. Rifampicin can be used as the first screening index of multidrug-resistant tuberculosis in Quanzhou area, according to the preliminary screening index to develop a reasonable treatment program to prevent MDR-TB.