头颈部恶性肿瘤的治疗一直困扰着耳鼻咽喉 -头颈外科医师 ,晚近提出的自杀基因疗法因其具有旁观者效应 ,能够直接杀伤肿瘤细胞 ,可诱导免疫应答等特点而倍受关注 ,本文试对自杀基因及其在头颈部恶性肿瘤治疗中的研究进展做一综述 The treatment of head and neck malignancy has been plagued by otolaryngology-head and neck surgeons. The recently proposed suicide gene therapy has attracted attention because of its bystander effect, its ability to directly kill tumor cells and induce immune responses. Suicide gene and its research progress in the treatment of head and neck cancer