植物通过细胞表面免疫受体识别来自于病原微生物的分子,激活天然免疫;而病原微生物通过向植物细胞分泌效应蛋白,这些蛋白往往通过翻译后修饰宿主蛋白,抑制天然免疫反应;植物通过进化,利用动植物中保守的、定位于胞质的NLR类型的免疫受体识别效应蛋白,重新激活免疫反应。研究胞内免疫受体识别病原微生物效应蛋白的分子机制不仅有助于理解植物与病原微生物间的进化关系,还能为研究动物 Plants recognize molecules from pathogenic microorganisms via cell-surface immune receptors and activate innate immunity. Pathogenic microorganisms, through the secretion of effector proteins to plant cells, often inhibit the innate immune response through posttranslational modification of host proteins. Through evolution and utilization of plants, The conserved, NLR-type immunoreceptor located in the cytoplasm of plants and animals recognizes the effector protein and reactivates the immune response. Studying the molecular mechanism by which intracellular immune receptors recognize pathogenic microbe-effector proteins not only helps to understand the evolutionary relationship between plants and pathogenic micro-organisms, but also studies animals