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本文研究了长期用磺脲类药物治疗的非胰岛素依赖型糖尿病(NIDDM)患者,在下述三种情况即:①停用磺脲类药物后,②每日1次服药法(OD),③每日3次服药法(TD),对一次标准饮食和一次试验用磺脲类药物血糖、胰岛素、C肽的反应。方法选择 NIDDM 患者14例,年龄35～75岁,基础代谢指数(BMI)20～30kg/M~2,肝、肾功能正常,仅使用饮食控制和磺脲类治疗。停用药物2周后测基础值,然后随机将受试者分为优降糖(GP)治疗组和吡磺环已脲(GB)治疗组,
This article studies the long-term use of sulfonylureas in patients with non-insulin-dependent diabetes mellitus (NIDDM), in the following three cases: ① after the withdrawal of sulfonylureas, ② once daily medication (OD), ③ each 3 times daily medication (TD), on a standard diet and a test with sulfonylureas blood sugar, insulin, C peptide reaction. Methods 14 patients with NIDDM were selected, aged from 35 to 75 years. The basal metabolic index (BMI) was from 20 to 30 kg / M ~ 2. The liver and kidney function were normal. Only diet control and sulfonylurea were used. After stopping the medication for 2 weeks, the basal values were measured, and then the subjects were randomly divided into glyburide (GP) treatment group and glipizide urea (GB) treatment group,