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瘙痒是肾病术期最常见的症状之一,见于约86％的透析患者,发病机理不明,虽有各种见解,但最近提示由组织胺引起的可能性大。作者研究了促红细胞生成素(erythropoietin,下称EP)对尿毒症病人瘙痒的疗效。共20例进行血液透析的尿毒症患者,10例有严重的癌痒;10例无瘙痒。EP的剂量为36u/kg,每周3次静注,直到红细胞容积达到或超过0.30,将Ep减量至18u/kg。有瘙痒的10例其中8例在EP治疗期间瘙痒明显改善,其瘙痒在停止EP治疗后一周内复发。瘙痒的改善与血红蛋白浓度的变化无关,
Pruritus is one of the most common symptoms of nephropathy, found in about 86% of dialysis patients, the pathogenesis is unknown, despite all sorts of opinions, but recently prompted the possibility of histamine caused by a large. The authors studied the efficacy of erythropoietin (EP) on pruritus in uremic patients. A total of 20 cases of hemodialysis patients with uremia, 10 cases of severe cancer itch; 10 cases without itching. EP dose of 36u / kg, intravenous injection three times a week until the erythrocyte volume reached or exceeded 0.30, Ep reduced to 18u / kg. In 10 of 10 cases with pruritus, pruritus significantly improved during the treatment of EP, and the pruritus recurred within one week after stopping EP treatment. The improvement of pruritus has nothing to do with the change of hemoglobin concentration,