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目的研究血糖浓度对脑PET/CT扫描中摄取~(18)-FDG的影响。方法回顾性分析2014年1月至2015年12月在我院行全身及头部PET/CT显像患者70例。所有患者在扫描前进行血糖检测,根据血糖浓度分为正常对照组、血糖稍高组和高血糖组,采用视觉分析和半定量分析的方法分析PET图像,以小脑皮质作为参考区域计算其最大化标准摄取值。结果正常对照组、血糖稍高组和高血糖组血糖水平逐渐升高,差异有统计学意义(F=200.369,P<0.05);三组相应小脑皮质SUVmax值逐渐降低,差异有统计学意义(F=14.207,P<0.05);组内两两比较高血糖组与正常对照组和血糖稍高组差异有统计学意义(P<0.05),而血糖稍高组与正常对照组相比血糖水平差异无统计学意义(P>0.05)。脑~(18)FDG摄取与血浆血糖水平呈负相关。结论高血糖水平干扰了脑组织~(18)-FDG的摄取,对PET/CT显像产生了一定影响,因此在PET/CT检查前需将血糖控制在合理范围内。
Objective To study the effect of blood glucose concentration on uptake of ~ (18) -FDG in brain PET / CT scan. Methods A retrospective analysis of 70 patients with whole body and head PET / CT in our hospital from January 2014 to December 2015 was performed. All patients underwent blood glucose test before scanning. According to the blood glucose concentration, the patients were divided into normal control group, slightly hyperglycemia group and hyperglycemia group. PET images were analyzed by visual analysis and semi-quantitative analysis, and the cerebellar cortex was calculated as the reference area Standard intake value. Results The blood glucose level of normal control group, slightly elevated glucose group and hyperglycemic group increased gradually (F = 200.369, P <0.05). The corresponding SUVmax of cerebellar cortex decreased gradually in three groups F = 14.207, P <0.05). There was a significant difference between the two groups of hyperglycemia group and the normal control group and slightly higher blood glucose group (P <0.05), while the blood glucose slightly higher group compared with the normal control group The difference was not statistically significant (P> 0.05). Brain ~ (18) FDG uptake was negatively correlated with plasma glucose level. Conclusion Hyperglycemia interfered with the uptake of ~ (18) -FDG in brain tissue and had some influence on PET / CT imaging. Therefore, it is necessary to control blood glucose within a reasonable range before PET / CT examination.