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调节型胞吐存在于神经元、内分泌细胞和外分泌细胞等可兴奋细胞以及免疫细胞等特化细胞中,是复杂而精确调节的分泌过程。其作用广泛,与神经信号传递、激素释放、免疫反应等重要的生理活动密切相关。调节型胞吐发生后,在分秒的时间尺度上,可兴奋性细胞快速启动与胞吐发生位置密切相关的调控型胞吞,回收细胞膜脂质和囊泡的膜蛋白,迅速清除分泌位点上由于胞吐而留下的蛋白以利于下一轮的分泌,回收并填充可释放囊泡库,维持细胞膜的平衡。该文先分别介绍可兴奋细胞中胞吐和胞吞的主要模式,然后探讨了它们之间耦联的机制。
Modulated exocytosis exists in neurons, endocrine cells and exocrine cells and other excitable cells and immune cells and other specialized cells, is a complex and precisely regulated secretion process. Its wide range of roles, and nerve signals, hormone release, immune response and other important physiological activities are closely related. Regulated exocytosis, on a time scale of seconds, excitatory cells can quickly start with exocytosis is closely related to the regulatory endocytosis, recovery of membrane lipid and vesicle membrane protein, the rapid elimination of secretory sites The protein left behind by exocytosis is conducive to the next round of secretion, recovery and filling can release the vesicle pool, to maintain the balance of the cell membrane. This paper first introduces the main patterns of exocytosis and endocytosis in excitable cells, and then explores the mechanism of the coupling between them.