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应用酶联免疫吸附测定法(ELISA),检测11119例孕妇静脉血和7643例新生儿脐血以及母儿配成5936对母儿的血清中,巨细胞病毒(HCMV)的特异性抗体 IgG、IgM,了解本市孕妇及围产儿感染情况,并调查 HCMV 感染对围产儿死亡和畸形的影响。结果:孕妇 HCMV-IgG 阳性率为76.94%,HCMV-IgM 阳性率为2%。新生儿脐血 HCMV-IgG 阳性率为50.54%,HCMV-IgM 陌性率为0.92%;配成5936对血清检测中,母体血清 HCMV-IgG 阳性率70.52%,脐血清阳性率51.01%,有72.34%的围产儿被动获得了母亲的 IgG 抗体;母体血清 HCMV-IgM 阳性率为1.79%,脐血 HCMV-IgM 阳性率为0.91%,有50.94%传播给围产儿致营内感染,导致围产儿的病死率为92.59‰、畸形率为7.4%,与其他因素引起的围产儿病死率(28.90‰)、畸形率(1.31‰)有显著差异(P<0.05)。
Application of enzyme-linked immunosorbent assay (ELISA), detection of 11,119 cases of pregnant women with venous blood and 7,643 newborn umbilical blood and maternal dubbed 5936 pairs of maternal serum, cytomegalovirus (HCMV) specific antibodies IgG, IgM , Understand the city’s pregnant women and perinatal infection, and investigate the impact of HCMV infection on perinatal death and deformity. Results: The positive rate of HCMV-IgG in pregnant women was 76.94%, and the positive rate of HCMV-IgM was 2%. The positive rate of neonatal cord blood HCMV-IgG was 50.54%, the rate of HCMV-IgM was 0.92%. The positive rate of HCMV-IgG was 70.52%, cord blood serum positive rate was 51.01% % Of the perinatal children passively received the mother’s IgG antibody; the positive rate of maternal serum HCMV-IgM was 1.79%, the positive rate of HCMV-IgM in umbilical cord blood was 0.91%, 50.94% spread to the perinatal infantile malnutrition, resulting in perinatal The case fatality rate was 92.59 ‰ and the deformity rate was 7.4%. The mortality rate of perinatal children (28.90 ‰) and deformity rate (1.31 ‰) was significantly different from other factors (P <0.05).