近年来有不少研究工作表明,曾被认为是无能的胚胎癌细胞(EC)株的F9细胞,在维生素A酸(简称RA)的影响下能分化成内胚层细胞或神经样细胞等。分化细胞的纤维蛋白溶酶原激活因子和胶原样蛋白都有显著增加,而且细胞表面的抗原、糖蛋白及植物凝集素受体等随之也发生明显变化。某些抗原(如F9抗原)随着分化会逐渐消失,而另一些抗原(如H-2抗原)又会出现。在细胞分化中植物凝集素受体的变化较为显著,其中最令人感兴趣的是花生凝集素受体(简称PNA In recent years, many studies have shown that F9 cells, once considered as impotent embryonic carcinoma (EC) strains, can differentiate into endodermal cells or neuron-like cells under the influence of retinoic acid (RA). Differentiated cells have a significant increase in plasminogen activator and collagen-like proteins, and cell surface antigen, glycoprotein and lectin receptors also followed significant changes. Some antigens (such as F9 antigen) will gradually disappear with the differentiation, and some other antigens (such as H-2 antigen) will appear again. The change of plant lectin receptor is more significant in cell differentiation. The most interesting one is peanut agglutinin receptor (PNA for short)