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2＇-5＇三腺苷酸-PPPA_2＇p5＇A_2＇p5＇A(2＇-5＇P_3A_3)及其同系物2＇-5＇ pAn,是干扰素作用于细胞后产生的一类不寻常的寡腺苷酸。我们曾发现2—5＇P_3A_3具有许多重要的生物功能,如广泛的抗病毒作用,对病毒感染细胞或组织有一定程度的保护作用,以及对机体免疫系统功能的调节等,而细胞膜上是否有它的受体,尚无人报导过。本工作证实巨噬细胞膜上存在2＇—5＇P_3A_3受体。我们用~3H—2＇—5＇P_3A_3与大鼠腹腔巨噬细胞保温,测得~3H-2＇—5＇P_3A_3能结合于巨噬细胞上,结合率约16％,这种结合具有饱和性和高亲和性,
2’-5 ’triadenylate-PPPA_2’p5’A_2’p5’A (2’-5’P_3A_3) and its homolog 2’-5’ pAn, is a class of interferon produced after the cells do not Ordinary oligoadenylic acid. We have found 2-5’P_3A_3 has many important biological functions, such as a wide range of antiviral effects, a certain degree of protection against virus-infected cells or tissues, and the regulation of the body’s immune system function, and the presence of cell membrane It’s receptor has not been reported yet. This work confirmed the presence of 2’-5’P_3A_3 receptors on macrophage membranes. We used ~ 3H-2’-5’P_3A_3 to incubate with rat peritoneal macrophages and found that ~ 3H-2’-5’P_3A_3 could bind to macrophages with a binding rate of about 16%. This binding was saturated Sexual and high affinity,