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人们一直认为,胃粘膜壁细胞的功能失调是溃疡病的主要病因,抗溃疡药组胺H_2受体阻断剂、多巴胺受体阻断剂、毒蕈碱型胆碱能受体阻断剂均作用于壁细胞而产生疗效。最近匈牙利两位学者Eva Mezey和Miklos Palkovits所做的实验对这一传统观点提出质疑。他们用组织化学杂交定位法显示出组胺H_2受体、M_1至M_5胆碱能受体、胃泌素受体及D_1至D_5多巴胺受体的mRNA在胃粘膜内的分布。结果表明,含有这些mRNA的阳
It has been thought that the dysfunction of gastric mucosa parietal cells is the main cause of ulcer disease, anti-ulcer agents histamine H 2 receptor blockers, dopamine receptor blockers, muscarinic cholinergic receptor blockers are Effect on parietal cells and produce curative effect. The recent experiments by two Hungarian scholars Eva Mezey and Miklos Palkovits challenged this traditional view. They used histochemical hybridization localization method to show histamine H 2 receptors, M 1 to M_5 cholinergic receptors, gastrin receptors and D_1 to D_5 dopamine receptors in the gastric mucosa. The results show that these mRNA containing Yang