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血管紧张素转化酶(ACE)抑制剂为高血压治疗学提供了一组有效而且耐受良好的药物。新开发的ACE抑制剂群多普利主要在肝脏水解为具有生物活性的代谢产物群多普利拉QrandolanrilaO,后者对ACE亲合力高,作用时间长。且药动学健康人口服群多普利后在1/J‘时内达血浆峰值,吸收率
Angiotensin-converting enzyme (ACE) inhibitors provide an effective and well-tolerated drug for hypertension therapy. The newly developed ACE inhibitor trandolapril is mainly hydrolyzed in the liver into a biologically active metabolite of QndolanolalaO, which has high affinity for ACE and long duration of action. And pharmacokinetics of healthy people after oral Dopple in 1 / J ’within the plasma peak, the rate of absorption