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妊娠期间母胎界面存在着复杂的免疫调控关系,蜕膜及绒毛作为母体及胎儿的直接接触面,是发生免疫反应的重要部位。多种细胞因子如转化生长因子-β、肿瘤坏死因子-α及血管内皮细胞等具有营养细胞、调控滋养细胞侵入、免疫抑制、防止母胎排斥等多种功能,他们在正常妊娠的维持中起着重要的作用。目前转化生长因子-β2的作用已越来越受重视,本文将从转化生长因子-β2与妊娠期高血压疾病存在的关系作如下综述。
Maternal and fetal interface during pregnancy there is a complex relationship between immune regulation, decidua and villus as the maternal and fetal direct contact surface, is an important part of the immune response. A variety of cytokines such as transforming growth factor-β, tumor necrosis factor-α and vascular endothelial cells with vegetative cells, regulating trophoblast invasion, immunosuppression, prevention of maternal fetal rejection and other functions, they maintain the normal pregnancy Important role. At present, the role of transforming growth factor-β2 has gained more and more attention. The relationship between transforming growth factor-β2 and hypertensive disorder complicating pregnancy is summarized as follows.