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本研究旨在了解糖尿病者肾功能损害时间(月或年)和血清肌酐对数(Iog Cr)或血清肌酐倒数(1/Cr)间是否存在线性关系,以及探索不同患者个体中可能引起肾功能减退速度显著不同的任何因素。9例病人(男5,女4),平均年龄32.8岁。平均糖尿病病程21.2年。均须依赖胰岛素和有糖尿病性视网膜病变,及有数年蛋白尿史。采用 SMA12/60或SMAC 自动分析仪测定血清肌酐。按每例数据,于血清肌酐达到200μmol/L 时的时间,和1/Cr 以及 logCr 之间的关系进行了线性回归分析。结果所有病人 Iog Cr 或1/Cr 和时间之间均显示有线性关系。1例病人当肌酐>500μmol/L 时观察到肾功能下降的终末性加速,此加速于利尿治疗开始时出现。病人肾功能减退速度与糖尿病确诊的年
The purpose of this study was to determine whether there is a linear relationship between the duration of renal impairment (months or years) and serum creatinine logarithm (Iog Cr) or serum creatinine reciprocal (1 / Cr) in patients with diabetes mellitus, as well as to explore the association between renal dysfunction The rate of decrease is significantly different for any factor. Nine patients (male 5, female 4), with an average age of 32.8 years. The average duration of diabetes 21.2 years. Both have to rely on insulin and diabetic retinopathy, and have a history of proteinuria for several years. Serum creatinine was measured using a SMA 12/60 or SMAC automated analyzer. Linear regression analysis was performed on the basis of each data, the time when serum creatinine reached 200 μmol / L, and the relationship between 1 / Cr and logCr. Results All patients showed a linear relationship between Iog Cr or 1 / Cr and time. One patient had a terminal acceleration of decline in renal function when creatinine> 500 μmol / L, which accelerated at the onset of diuretic therapy. The rate of renal dysfunction in patients and the year of diagnosis of diabetes