帕金森病(PD)是以运动功能失调为主要表现的神经退行性疾病,其病理特征是黑质致密部多巴胺能神经元的丢失和路易氏小体的形成。线粒体能量供应障碍和氧化应激在PD发生与发展过程中起重要作用,抗氧化和改善线粒体功能的物质可延缓PD的发展。维生素B_3是体内氧化还原体系的重要组分,参与抗氧化、抗炎、促进自噬以及维护神经元正常结构和功能,提示补充维生素B_3可能是延缓PD的方法之一。 Parkinson’s disease (PD) is a neurodegenerative disease mainly characterized by motor dysfunction. Its pathological features are loss of substantia nigra dopaminergic neurons and formation of Lewy bodies. Mitochondrial dysregulation of energy supply and oxidative stress play an important role in the development and progression of PD. Antioxidant and mitochondrial functions can delay the development of PD. Vitamin B_3 is an important component of redox system in vivo. It is involved in anti-oxidant, anti-inflammatory, autophagy and normal structure and function of neurons, suggesting that vitamin B_3 may be one of the ways to delay PD.