抑癌基因PTEN与肿瘤血管生成研究进展

来源 :江苏省药理学会第六届学术研讨会 | 被引量 : 0次 | 上传用户：neiki1120

【摘要】

：

PTEN是具有磷酸脂酶活性的抑癌基因,是双特异蛋白磷酸酶家族(DSPs)的成员,同时具有脂质磷酸酶和蛋白酪氨酸磷酸酶活性。而在肿瘤增殖,侵袭,迁移的过程中,肿瘤血管生成作为肿瘤发生发展中一个关键因素已越来越受到人们的关注。抑癌基因PTEN可以参与PI3K/Akt信号通路,调控缺氧诱导因子1,基质金属蛋白酶,血管内皮生长因子,钠氢交换调控因子1,酪氨酸激酶受体等血管生成相关信号以及一些机体氧化产物来

【作者】

：

沈存思范方田陶丽郑仕中王爱云陆茵

【机构】

：

南京中医药大学药学院南京中医药大学药学院;江苏省中药药效与安全性评价重点实验室江苏南京2100

【出处】

：

江苏省药理学会第六届学术研讨会

【发表日期】

：

2012年12期

【关键词】

：

抑癌基因 PTEN 肿瘤血管生成 PI3K/Akt信号通路

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抑癌基因PTEN与肿瘤血管生成研究进展

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