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Since chemoresistance is a complicated and multifactorial factor in breast cancer,systematically characterize metabolic perturbation of endogenous compounds associated with drug resistance may providecandidate biomarkers or novel drug targets.The current study examined the different metabolites between senstivebreast cancer MCF-7/S and adriamycin-resistant MCF-7/Adr and their differentresponse to adriamycin.GC-TOF/MS-based metabonomic analysis revealed the different metabolic patterns between these two cell lines and the discriminatory metabolites suggested the nucleotides metabolism,glutathione biosynthesis,glucose metabolism and glycerol metabolism were reprogrammed.These