ligands相关论文
Ligand-Conjugated siRNA Delivery Systems Localizes in Hepatocytes and Elicits Robust RNAi-Mediated G
Synthetic small interfering RNAs(siRNAs)can inhibit expression of disease-causing genes through post-transcriptional gen......
Molecular Structures and Catalytical Performance in Suzuki-coupling Reaction of Novel Dipalladium Cl
Laboratory for Self-assembly Chemistry,Center of Excellence for EA series of clip-shaped cationic molecular corners C1~C......
Unusual Coordination Mode of Tetradentate Diiminedioxime Ligand in a Mononickel(Ⅱ) Complex:Synthesis
In this work, it is found that 1,8-dihydroxyimino-1,2,7,8-tetraphenyl-3,6-diazocta-2,6-diene(PhdoenH2) could react with ......
Synthesis,Structure and Theoretical Calculation of Metal Coordination Polymers with Pyrazine-2,3-dic
A new 2D metal coordination polymer(MCP),[Mn(pzdc)0.5(L)]n(1,pzdc=pyrazine-2,3-dicar-boxylic acid,HL=3-(2-pyridyl)pyrazo......
The interaction between the Mn-cluster and its peripheral ligands in oxygen-evolving center is still unclear. Theoretica......
Synthesis,Crystal Structure and Theoretical Calculations of a Zinc(Ⅱ) Coordination Polymer Assembled
A new metal-organic coordination polymer [Zn(pzdc)(mbix)]_n·nH_2O(H_2pzdc = pyrazine-2,3- dicarboxylic acid, mbix = 1,3......
Syntheses and Crystal Structures of Two Copper(Ⅱ) Coordination Polymers Derived from Aromatic Carbox
Two compounds have been obtained by the reaction of metal(Cu(II)), 4,4?-bis(imidazol-l-yl)diphenyl thioether(BIDPT) with......
Hydrothermal Syntheses,Crystal Structures,and Characterization of Two Zinc(Ⅱ) Complexes Containing F
Two zinc(Ⅱ) complexes, namely, [Zn(L_1)Cl_2]_2(1) and {[Zn(L_2)(tbta)]·3H_2O}n(2)(L_1 = 1,3-bis(2-methylbenzimidazol-1......
目的探索生物纳米盘(Nanodisc)在G蛋白偶联受体(GPCR)体外功能和药物筛选研究方面的应用。方法将重组表达获得的5-羟色胺2B受体(5-......
目的 探讨转染FasL基因的供者树突状细胞(DC)对小鼠心脏移植排斥反应的影响.方法 分离并培养C57BL/6小鼠骨髓DC,然后采用脂质体法......
目的 探讨血管紧张素Ⅱ(AngⅡ)对肺微血管内皮细胞APJ mRNA和Apelin mRNA表达的影响.方法 培养并鉴定24 h新生SD大鼠肺微血管内皮......
报道了一系列β（三氯锡烷基）丙酸丁酯配合物的合成和光谱表征，并对它们的红外光谱和核磁共振氢谱进行了讨论。这些配合物抑制Ｅｈｒｌｉｃｈ腹水癌......
Electron－rich Polynuclear Transition Metal Clusters：Ⅰ． The Clusters with Chalcogen Bridges and Phosp
Ｅｌｅｃｔｒｏｎ－ｒｉｃｈＰｏｌｙｎｕｃｌｅａｒＴｒａｎｓｉｔｉｏｎＭｅｔａｌＣｌｕｓｔｅｒｓ：Ⅰ．ＴｈｅＣｌｕｓｔｅｒｓｗｉｔｈＣｈａｌｃｏｇｅｎＢｒｉｄｇｅｓａｎｄＰｈｏｓｐｈｉｎｅＬｉｇａｎｄｓＨｏｎｇＭａｏ－Ｃｈｕｎ；ＪｉａｎｇＦｅｉ－Ｌｏｎ...
Electron-richPolynuclearTransitionMetalClusters: Ⅰ. TheClusterswithChalcogenBridgesandPhosphineLigandsHongMao-Ch......
ＴｅｍｐｌａｔｅＳｙｎｔｈｅｓｉｓａｎｄＳｔｒｕｃｔｕｒｅｏｆＤｉｎｕｃｌｅａｒＺｉｎｃＣｏｍｐｌｅｘｗｉｔｈＴｈｒｅｅＫｉｎｄｓｏｆＰｙｒａｚｏｌｅＬｉｇａｎｄｓＺＨＡＮＧＷｅｎ－Ｘｉｎｇ；ＭＡＣｈａｎｇ－Ｑｉｎ；ＷＡＮＧＸｕ－Ｎｉｎｇ；ＹＵＺｈｅ...
Template Synthesis and Structure of Dinuclear Zinc Complex with Three Kinds of Pyrazole Ligands ZHANG Wen-Xing; MAC......
The crystal structure of the title compound, C 26 H 27 O 6P, has been determined by single crystal X ray diff......
Carbon-free D_(3d) [E_3ME_3]~(2-) (E=P,As;M=Ni,Pd,Pt):The smallest inorganic sandwich complexes with
A density functional theory and wave function theory investigation on the possibility of carbon-free phosphametallocenes......
ＭｏｄｉｆｉｅｄＤＴＰＡ，ＥＤＴＡＬｉｇａｎｄｓａｎｄＴｈｅｉｒＰａｒａｍａｇｎｅｔｉｃＭｅｔａｌＣｏｍｐｌｅｘｅｓａｓＣｏｎｔｒａｓｔＡｇｅｎｔｓｆｏｒＭＲＩ￥ＺｈｕｏＲｅｎｘｉ；ＦｕＧｏｎｇｃｈｅｎｇ；ＯｕｙａｎｇＭｉｎｇ；ＺｈａｏＸｉａ；ＬｕＺ...
ModifiedDTPA, EDTALigandsandTheirParamagneticMetalComplexesasContrastAgentsforMRI ¥ ZhuoRenxi; FuGongcheng; Ouyang......
As balanced electron-rich P,C-chelating ligands, phosphine-phosphonium-ylides are considered for their ability to in sit......
细胞膜屏障在保护细胞正常形态和功能的同时,也使很多有治疗作用的生物活性分子难以进入细胞内,使其应用受到极大限制.目前常用的......
配体修饰的聚合物胶束除了具有一般聚合物胶柬所具有的稳定性好、载药范围广等优点外。还能主动靶向于特定的组织、器官,从而成为......
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,Identification of a sugar gustatory receptor and its effect on fecundity of the brown planthopper N
In insects,the gustatory system plays a crucial role in multiple physiological behaviors,including feeding,toxin avoidan......
单克隆抗体、多克隆抗体及抗体片段在科学研究和医药领域中的位置越来越重要,抗体的纯化技术也在不断发展.疏水电荷诱导层析是最近......
目的建立实时荧光定量聚合酶链反应(RFQ-PCR)检测非小细胞肺癌(NSCLC)患者痰中增殖诱导配体(APRIL)mRNA含量的方法,探讨痰脱落细胞......
基于人类脑神经型烟碱乙酰胆碱受体(nAChRs) PET显像的研究已取得显著进展,尤以脑内最主要的nAChRs亚型,即α4β2亚型nAChRs(α4β......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
目的研究过氧化物酶体增生物激活受体γ( PPAR γ)经配体活化后抑制肺癌生长的机制.方法通过 RT-PCR和 Western blot检测肺癌细胞......
Summary: To study the expression of peroxisome proliferator-activated receptor-γ(PPAR-γ) in lungcancer cells, and to t......
膜蛋白P84(SHPS-1)及其配体IAP(integrin associated protein,integrin相关蛋白)均在中枢神经系统及其后神经外组织表达并参与信息......
过氧化物酶增殖物激活受体(peroxisome proliferator activated receptors,PPAR)是一类配体依赖性的核转录因子,调控多种基因表达.......
目的 研究程序性死亡分子-1(PD-1)及其配体(PD-L1)表达水平与慢性HBV感染者HBV DNA水平的相关性及抗病毒治疗对其表达的影响.方法 ......
[目的]探讨食管癌中程序性死亡因子配体-1 (PD-L1)的表达情况及与病情的相关性.[方法]以100例健康体检者及100例食管癌作为观察对......
S100 A7是一种小分子钙结合蛋白，广泛参与到上皮细胞的分化、皮肤化学防御体系的构建、氧化应激和炎症反应的发生等生命过程，其分泌......
G-protein coupled receptor (GPCR) is one of the most important protein families for drug target. GPCR agonists and antag......
目的 研究过氧化物酶体增生物激活受体γ（PPAR-γ）经配体活化后抑制肺癌生长的机制。方法 通过RT-PCR和Western blot检测肺癌细胞株......
背景：在神经系统的发育中，音猬因子信号通路的主要作用为诱导整个中枢神经系统形成背腹两侧分区,当这一信号通路受到破坏时，将导致整......
目的:探讨TRAIL对胶质瘤化疗敏感性的影响及其诱导细胞凋亡的原理.方法:人脑胶质瘤U251细胞株培养成功后,应用MTT法检测TRAIL和VM2......
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目的:探讨新型凋亡分子TNF相关凋亡诱导配体(TRAIL)对人肝癌细胞系的作用及生物学活性的影响.方法:免疫细胞化学法检测HepG2细胞表......
以2-（2,4，6-Me3C6H2N=CH）C4H3NH为配体与铕配合物[（Me3Si）2N]，Eu（μ-C1）Li（THF），反应，合成了三价铕金属配合物[2-（2，4，6-Me3C6H2N=CH）C4H3N]3Eu（THF），......
This study is focused in the influence of some experimental factors on direct ^99mTc monoclonal antibody labelling metho......
近年来以G-四链体DNA为药物靶点的研究引起了人们的广泛关注,G-四链体与其配体相互作用的研究方法也多种多样。本文对研究G-四链体......
目的观察冠心病患者血清可溶性OX40配体（sOX40I，）和高敏C反应蛋白（hs-CRP）水平的变化，探讨sOX40L和hs—CRP与冠状动脉粥样斑块稳定性的关......
G四链体(G-quadruplex)是一种由DNA或者RNA构成的非典型核酸二级结构,广泛存在于生物体内,调节基因转录、复制等功能。然而,在生物......
依据药物作用的靶分子结构进行新药设计,作为药物研究中的新方法使新药的研发过程正在从一种偶然性、经验性的过程逐渐走向一种合......
目的:探讨来源于不同组织肺泡、腹腔巨噬细胞甘露糖受体(macrophage mannose receptor, MMR)与配体的亲和力差异.方法:采用支气管......
Screening of aptamers and their potential application in targeted diagnosis and therapy of liver can
Aptamers are a class of single oligonucleotide molecules(DNA or RNA)that are screened from random DNA or RNA oligonucleo......
SYNTHESIS AND STRUCTURE OF A 2D SHEET－LIKE COPPER（II） COMPLEX WITH BRIDGING PYRIDINE－4－CARBOXYLATE A
ＳＹＮＴＨＥＳＩＳＡＮＤＳＴＲＵＣＴＵＲＥＯＦＡ２ＤＳＨＥＥＴ－ＬＩＫＥＣＯＰＰＥＲ（ＩＩ）ＣＯＭＰＬＥＸＷＩＴＨＢＲＩＤＧＩＮＧＰＹＲＩＤＩＮＥ－４－ＣＡＲＢＯＸＹＬＡＴＥＡＮＤＴＲＡＮＳ－ＯＸＡＭＩＤＡＴＥＬＩＧＡＮＤＳ￥ＭｅｉＦａｎｇＷｕ；Ｚｈ.........
Alkoxy substituted MeO-BIPHEP-type diphosphines ligands for asymmetric hydrogenation of aryl ketones
In this paper,a series of optically active MeO-BIPHEP-type ligands,（S）-6,6′-dimethoxy-2,2’-bis（di-p-alkoxyphenylphosphine......
