TRIPTOLIDE相关论文
White matter injury is the major pathological alteration of subcortical ischemic vascular dementia(SIVD)caused by chroni......
Synergetic delivery of triptolide and Ce6 with light-activatable liposomes for efficient hepatocellu
Hepatocellular carcinoma(HCC)has been known as the second common leading cancer worldwide,as it responds poorly to both ......
To design a new type of antitumor nanodrug carrier with good biocompatibility,a drug delivery system with a 2.19％ drug-lo......
As a major active component extracted from traditional Chinese herb Tripterygium wilfordii Hook F,triptolide exhibits mu......
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Triptolide (TP) induces severe liver injury,but its hepatotoxicity mechanisms are still unclear.Inflammatory responses m......
Differential expression of the TwHMGS gene and its effect on triptolide biosynthesis in Tripterygium
3-Hydroxy-3-methylglutaryl-CoA synthase (HMGS) is the first committed enzyme in the MVA pathway and involved in the bios......
Atractylodes lancea rhizome water extract reduces triptolide-induced toxicity and enhances anti-infl
The present study was designed to explore the influence of water extracts of Atractylodes lancea rhizomes on the toxicit......
UPLC/ESI-QTOF-MS-based metabolomics survey on the toxicity of triptolide and detoxication of licoric
Triptolide (TP) from Tripterygium wilfordii has been demonstrated to possess anti-inflammatory,immunosuppressive,and ant......
Triptolide reduces prostate size and androgen level on testosterone-induced benign prostatic hyperpl
Benign prostatic hyperplasia (BPH) is an age-related disease of unknown etiology,characterized by prostatic enlargement ......
Co-delivery of doxorubicin and triptolide with reduction-sensitive lipid-polymer hybrid nanoparticle
Co-delivery is a promising strategy to overcome the limitations of single chemotherapeutic agent in cancer treatment.Des......
采用超临界二氧化碳结合高压溶剂从雷公藤根部萃取雷公藤甲素。通过考察高压溶剂的 种类、浓度、加入方式和流速，以及萃取温度和萃......
Triptolide is a monomeric compound isolated from a traditional Chinese herb,tripterygium wilfordii Hook.f.(TWHF)....
Parkinsons disease(PD)has become a social problem in China,seriously affecting population health and life quality and in......
Myocardial expression of Foxp3 in cardiac hypertrophy induced by isoprenaline and effect of triptoli
Aim: Inflammation and immune have been demonstrated to be involved in the pathophysiological process of cardiac hypertro......
Synergistic Anticancer Effects of Triptolide and Celastrol, Two Main Compounds from Thunder God Vine
Objective Triptolide and celastrol are two most widely studied and promising compounds isolated from Thunder God Vine (T......
Aim To explore the role of transcription factor Foxp3 and the regulating effect of triptolide (TP) in the progression of......
Renal-targeting triptolide-glucosamine conjugate exhibits lower toxicity and superior efficacy in at
We previously reported a novel triptolide(TP)-glucosamine conjugate(TPG)that specifically accumulated in kidneys and pro......
Triptolide improves learning and memory behavior of the 5XFAD transgenic mice accompanied by suppres
Triptolide (T10) is a major active component of the traditional Chinese medicine, Tripterygium wilfordii Hook F (TWHF), ......
Formulation of Triptolide-Ioaded Microemulsion Hydrogel and Its Potential Anti-Psoriasis Activity in
Psoriasis is a kind of chronic,autoimmune disease affecting approximately 2%of the population.As an active immunosuppres......
Adeno-associated virus (AAV)-mediated gene transfer has been demonstrated to be an effective approach for treating Parki......
Parkinsons disease (PD) is a neurodegenerative disease that results from the progressive loss of dopaminergic neurons in......
Triptolide is often used to treat patients with immunoglobulin A nephropathy(IgAN),especially in Asia.However,its detail......
pH-Sensitive Nanoformulated Triptolide as a Targeted Therapeutic Strategy for Hepatocellular Carcino
Objective: we work on the designed synthesis of a tumor-responsive nanoformulated triptolide (Nf-Trip)for HCC targeted t......
The correlation of polylactosamine catalyzed by β3GnT8 and drug-resistance of leukemia cells K562/br
Objectives: In order to explore the relationship between polylactosamine chains and leukemia cells SAHA-resistant and th......
The novel and potent anti-depressive action of triptolide in a rat model of the comorbidity of chron
Chronic pain and depression frequently coexist in clinical settings while the current clinical treatment for this comorb......
Effect of triptolide on hypertrophic response and expression of P53 in neonatal rat ventricular myoc
Objective: To investigate the effects of triptolide on the hypertrophic response and expression of P53 in neonatal rat v......
Objective: To explore roles of triptolide in the regulation of T cell subsets in the asthma.Methods: C57BL/6J mice expos......
Adeno-associated virus (AAV) mediated gene transfer has been demonstrated to be an effective approach for treating Parki......
Triptolide,a Chinese herbal extract, inhibits COX-2 protein expression and PGE2 release by down-regu
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Objective: To provide theoretical basis for the drug treatment of RA by studying effect of triptolide on the gene of col......
Individual variances usually affect drag metabolism and disposition, and hence result in either ineffectiveness or toxic......
Triptolide Inhibits Expression of Inflammatory Cytokines and Proliferation of Fibroblast-like Synovi
Triptolide,a component of the Chinese herb Tripterygium wilfordii Hook F,has been proved to be effective in the treatmen......
Triptolide suppresses the growth and metastasis of non-small cell lung cancer by inhibiting β-cateni
Non-small cell lung cancer (NSCLC) is characterized by a high incidence of metastasis and poor survival.As epithelial-me......
Superior in vitro anticancer effect of biomimetic paclitaxel and triptolide co-delivery system in ga
As a well-known anticancer drug,paclitaxel(PTX),a first-line chemotherapeutic agent,remains unsatisfactory for gastric c......
Background:Dysfunction or loss of podocytes causes proteinuria,which has been associated with both acute and chronic......
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目的：观察雷公藤甲素对Ⅱ型胶原诱导的关节炎(CIA)大鼠外周血γδ6T细胞表达细胞因子TNF-α和IL-10的影响，探讨γδ6T细胞在CIA中的......
目的研究雷公藤内酯醇（TL）对人纤维肉瘤HT-1080细胞表达基质金属蛋白酶（MMP）-2和-9的影响。方法以终浓度分别为6、12和18nM的TL处理HT-......
目的:制备包载雷公藤甲素的壳聚糖纳米粒系统(triptolide-chitosan nanoparticles,TP-CS NPs),并考察其理化性质及体外释药性能。......
Triptolide reduces prostate size and androgen level on testosterone-induced benign prostatic hyperpl
Benign prostatic hyperplasia(BPH) is an age-related disease of unknown etiology, characterized by prostatic enlargement ......
目的 以胶原诱导的关节炎(CIA)为动物模型,探讨雷公藤甲素(triptolide)能否诱导CIA大鼠滑膜细胞凋亡。方法 选用雄性Wistar大鼠造......
目的:以聚乙二醇单硬脂酸酯表面修饰材料结合到固体脂质纳米粒(solid lipid nanoparticles,SLN),以雷公藤内酯醇(triptolide,TPL)......
BACKGROUND: Studies have demonstrated that triptolide has good anti-inflammatory and immunosuppressive effects. However,......
The Effects of Triptolide on HLA Antigens Expression of Corneal Epithelial Cells Induced by Interfer
Objective: To observe the effects of immunosuppressants triptolide (TL) and cyclosporine A (CSA) on HLA antigens express......
目的 探讨雷公藤内酯醇(TP)对人胰腺癌PANC1细胞株侵袭能力的影响及其与Toll样受体4/核因子-KB(TLR4/NF-KB)信号通路的关系.方法 ......
Inhibitive effect of triptolide on invasiveness of human fibrosarcoma cells by downregulating matrix
Objective:To explore the molecular mechanisms of antitumor properties of triptolide, a bioactive component isolated from......
