Conjugates相关论文
Rational design, synthesis and anti-tubercular evaluation of novel 1H-1,2,3-triazole-linked gatiflox
Hybridization,which is on the basis of the combination of two or more different pharmacophore moieties of different bioa......
Preparation of Oxaliplatin-Mesoporous Silica Nanoparticle Conjugates and Their Application in Cancer
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Conjugation of a Nonspecific Antiviral Sapogenin with a Specific HIV Fusion Inhibitor:a Promising St
Triterpene saponins are a major group of active components in natural products with universal antiviral activities.Previ......
会议
Redox-sensitive hyaluronic acid-paclitaxel conjugate micelles with high physical drug loading for ef
The design of targeted polymer-drug conjugate capable of controlled drug release remains a benchmark for drug delivery s......
Design,synthesis and biological evaluations of isoniazid/pyrazinamide/ethambutol-quinoline conjugate
A series of novel isoniazid/pyrazinamide/ethambutol-quinoline conjugates based on the commonality in the structures of a......
Development of biodegradable polymeric implants of RGD-modified PEG-PAMAM-DOX conjugates for long-te
Objective: The sustained release implants which can be directly implanted in the tumor site by surgery seem to be a prom......
Identification and Structure-Activity Relationships of Novel Dual-acting Agents to Improving Therape
The development of estrogen receptor(ER)ligands has emerged as active study field in fight against breast cancer,some of......
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以己二酰肼为间桥，碳二亚胺为偶联剂，将纯化的血清8型荚膜多糖和纯化的CIfA—FnBPB融合蛋白偶联制备偶联物，并在偶联的过程中确定其最......
Fluorescein isothiocyanate-labeled insulin (FITC-insulin) has been widely used for bioanalytical appli-cations. Due to t......
ＩｎｔｒｏｄｕｃｔｉｏｎＧｌｕｔａｔｈｉｏｎｅｐｅｒｏｘｉｄａｓｅ（ＧＰＸ）ｆｕｎｃｔｉｏｎｓａｓｏｎｅｏｆａｎｔｉｏｘｉｄａｎｔｄｅｆｅｎｃｅｅｎｚｙｍｅｓｔｏｒｅｄｕｃｅａｗｉｄｅｖａｒｉｅｔｙｏｆｉｎｔｒａｃｅｌｕｌａｒｐｅｒｏｘｉｄｅｓ，ｉｎ...
IntroductionGlutathioneperoxidase (GPX) functionsasoneofantioxidantdefenceenzymestoreduceawvarvarietyofintracelular......
The site of attachment of protein carrier to corticosteroids has great influence on the specificity of produced antibody......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
以黄原胶为多糖供体，辅以超声波辅助处理，对马铃薯蛋白进行糖基化改性。结果表明：糖基化复合物乳化特性受反应物配比、干热反应时间和......
霍乱是经粪口传播的烈性传染病，相应的疫苗研究已逾百年，但目前还没有理想的疫苗。实验中以霍乱O1群小川血清型的脂多糖为目标抗原，用......
采用自动形滴张力测量法对蛋白-多糖复合物的界面流变特性进行了研究。结果表明,SPI-KC复合物在油-水界面上形成的界面膜为粘弹性......
通过可控干热法制备壳聚糖和大豆分离蛋白共价复合物，并将其与天然乳胶共混制成共混膜。壳聚糖和大豆分离蛋白共混液与共价复合物的......
目的：介绍四环素-阿霉素复合物（ADM-Dex-TC）的制备方法,探讨复合物作为靶向性抗癌药物的性质.方法：以多醛基葡聚糖（Polyaldehyde Dextra......
目的寻求用聚乙二醇对甲氨蝶呤进行化学修饰的新方法，探讨甲氨蝶呤-聚乙二醇偶联物的体外缓释特征。方法用微波催化结合化学催化合......
通过乙酰水杨酸（ASA）分别与噻菌灵、三唑醇和噁霉灵3种杀菌剂拼接,合成了未见文献报道的ASA-噻菌灵、ASA-三唑醇、ASA-噁霉灵的藕合......
N-(2-Hydroxypropyl ) methacrylamide copolymer-5-fluorouracil (PHPMA-FU ) 结合被一条新奇、简化的合成路线综合，并且描绘了由......
设计合成氟尿嘧啶—大豆素拼合物,并考察其对HepG2细胞增殖抑制活性。以氟尿嘧啶为先导物,与氯乙酸反应制得5-氟脲嘧啶-1-基乙酸,......
In the present study,an anti-gastric cancer monoclonal antibody MGb<sub>2</sub>-daunomycin（DM）conjugate was prepared by ci......
Fluorescein isothiocyanate-labeled insulin(FITC-insulin)has been widely used for bioanalytical applications.Due to the h......
目的设计、合成抗肿瘤药物吉西他滨与聚谷氨酸的偶合物,通过调节连接子的结构以控制药物的释放,提高抗肿瘤药物的疗效。方法首先合......
报道了甘油脂与Ｇｅｒｍａｔｒａｎｅｓ缀合物的合成，合成中以ＤＣＣ为缩合剂，以吡啶为催化剂，经缩合反应得到目标产物，对缩合方法和反应条件进行了探讨，化合物结构经......
以碘活化的六乙基亚磷酰三胺为磷酰化及环化试剂，经一锅法合成并分离得到硫代环磷酸酯的两个非对映异构体，并对这两个非对映异构体的......
目的设计、合成具有抗肿瘤活性的烷氧基联苯/C5-姜黄素偶联物。方法以双环醇、丙酮及不同取代的苯甲醛为原料，经吡啶氯铬酸盐（pyridi......
TCR-mimic antibody-drug conjugates targeting intracellular tumor-specific mutant antigen KRAS G12V m
Limited clinical application of antibody-drug conjugates(ADCs)targeting tumor associated antigens(TAAs)is usually caused......
Fluorescent probes with high signal/background ratio are needed for hybridization assays. Hence, the chromophore of gree......
ＩｎｔｒｏｄｕｃｔｉｏｎＧｌｕｔａｔｈｉｏｎｅｐｅｒｏｘｉｄａｓｅ（ＧＰＸ）ｆｕｎｃｔｉｏｎｓａｓｏｎｅｏｆａｎｔｉｏｘｉｄａｎｔｄｅｆｅｎｃｅｅｎｚｙｍｅｓｔｏｒｅｄｕｃｅａｗｉｄｅｖａｒｉｅｔｙｏｆｉｎｔｒａｃｅｌｕｌａｒｐｅｒｏｘｉｄｅｓ，ｉｎ.........
Natural polyamine is an ideal antitumor drug carrier because of the great requirement difference between cancer cells an......
以人血浆组份Ⅳ为原料，经过多纯化及铁饱和，得到纯度为９９％的铁饱和转铁蛋白（Ｈｏｌｏ－ｔｒａｎｓｆｅｒｒｉｎ，Ｈｏｌｏ－ＴＦ）：以转铁蛋白（Ｔｒａｎｓｆｅｒｒｉｎ，ＴＦ）为载体，采用两种不同的偶联方法制备ＴＦ－氨甲喋呤（Ｍｅｔｈｏｔｒｅｘａｔｕｍ，ＭＴＸ）偶联物......
Colorectal cancer(CRC)is often diagnosed at an advanced stage when tumor cell dissemination has taken place.Chemo-and ta......
QSAR Studies on the Inhibitory Activityof Levofloxacin-thiadiazole HDACi Conjugates to Histone Deace
A molecular electronegativity distance vector(Mt)based on 13 atomic types has been used to describe the structures of 19......
Active targeted drug delivery methods facilitate effective uptake of functionalized nanoparticles through receptor-media......
