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目的探究子宫内膜息肉(EP)患者的胰岛素抵抗状态及其危险因素。方法选取2015年6月-2016年2月在郑州大学第三附属医院妇科就诊的90例EP患者为病例组,90例非EP患者为对照组,统计两组患者年龄、体重指数(BMI)、血压及腹围;检测血液胰岛素释放试验4次、葡萄糖耐量试验4次、性激素及血脂,计算稳态模型胰岛素抵抗指数(HOMA-IR)。结果两组患者HOMA-IR、空腹胰岛素、胰岛素120 min、服糖后1 h、2 h、3 h血糖、总胆固醇及腹围比较,差异均有统计学意义(P<0.05);年龄、BMI、高血压及性激素水平比较,差异均无统计学意义(P>0.05);两组胰岛素抵抗者分别占60.00%和28.89%,差异有统计学意义(χ~2=17.640,P=0.000,r=0.299)。多因素Logistic回归分析显示,EP的影响因素是HOMA-IR及腹围(OR=4.423,OR=2.496)。结论胰岛素抵抗与EP的发生呈正相关。
Objective To investigate the status of insulin resistance and its risk factors in patients with endometrial polyps (EP). Methods Ninety patients with EP who visited gynecology department of the Third Affiliated Hospital of Zhengzhou University from June 2015 to February 2016 were selected as the case group and 90 non-EP patients as the control group. The age, body mass index (BMI) Blood pressure and abdominal circumference were measured. The blood insulin release test was conducted 4 times, glucose tolerance test 4 times, sex hormones and blood lipids, and the homeostasis model insulin resistance index (HOMA-IR) was calculated. Results There were significant differences in HOMA-IR, fasting insulin, insulin 120 min, blood glucose at 1 h, 2 h, 3 h after oral administration, total cholesterol and abdominal circumference between the two groups (P <0.05) , Hypertension and sex hormone levels, the difference was not statistically significant (P> 0.05); two groups of insulin resistance accounted for 60.00% and 28.89%, the difference was statistically significant (χ ~ 2 = 17.640, P = 0.000, r = 0.299). Multivariate Logistic regression analysis showed that the influential factors of EP were HOMA-IR and abdominal circumference (OR = 4.423, OR = 2.496). Conclusion Insulin resistance is positively correlated with the occurrence of EP.