高效液相色谱技术 (highperformanceliquidchromatography .HPLC)具有分离效率高、速度快、灵敏度高、流动相可选择范围宽 ,色谱柱可反复使用 ,流出组分易于收集、安全等特点 ,是现今应用最广泛的分析技术。由于口腔标本数量少、含量低、非常适宜于HPLC分析 ,所以近年来在口腔医学研究领域应用越来越广泛。本文主要阐述了近五年来国内外此技术在口腔领域中的研究成果 High performance liquid chromatography (HPLC) has the characteristics of high separation efficiency, high speed, high sensitivity, wide range of mobile phase options, reusable columns, easy to collect effluent components, and safety features. It is the most widely used analytical skills. Due to the small number of oral specimens, low content, very suitable for HPLC analysis, so in recent years in the field of oral medicine research is more and more widely used. This article mainly expounds the research results of this technique in the oral field both at home and abroad in the past five years