论文部分内容阅读
抗神经元抗体是一组作用于神经元的抗体,这些抗体通常发现于某些特殊的中枢神经系统疾病如边缘叶脑炎、抗N-甲基-D-天冬氨酸受体(NMDAR)脑炎、僵人综合征、Morvan综合征等患者的血清和(或)脑脊液中。这些抗体的发现为许多中枢神经系统疾病发病机制的研究提供了新的视角,并且为这些疾病的治疗提供了新的方向,在很大程度上改变了这些疾病的预后。并且,随着检测方法的不断提高,新发现的抗体种类不断增加,抗神经元抗体相关的中枢神经系统疾病谱也随之扩大。因此,我们对这些抗体相关的中枢神经系统疾病进行综述,以期为基础研究及临床工作提供一定的指导。
Anti-neuronal antibodies are a group of antibodies that act on neurons that are commonly found in certain specific central nervous system disorders such as limbic encephalitis, anti-N-methyl-D-aspartate receptor (NMDAR) Encephalitis, Stiff-Man syndrome, Morvan syndrome and other patients with serum and / or cerebrospinal fluid. The discovery of these antibodies provides a new perspective for the study of the pathogenesis of many central nervous system diseases and provides a new direction for the treatment of these diseases and greatly changes the prognosis of these diseases. Moreover, with the continuous improvement of detection methods, the newly discovered antibody types have been continuously increased, and the spectrum of central nervous system diseases related to anti-neuronal antibodies has also been expanded. Therefore, we summarize these antibody-related CNS diseases in order to provide some guidance for basic research and clinical work.