AIM:To investigate the effects of gastric pacing on gastricemptying and plasma motilin level in a canine model of gastricmotility disorders and the correlation between gastricemptying and plasma motilin level.METHODS:Ten healthy Mongrel dogs were divided into:experimental group of six dogs and control group of fourdogs.A model of gastric motility disorders was establishedin the experimental group undergone truncal vagotomycombined with injection of glucagon.Gastric half-emptyingtime (GEt_(1/2)) was monitored with single photon emissioncomputerized tomography (SPECT),and the half-solid testmeal was labeled with an isotope-~(99m)mTc sulfur colloid.Plasmamotilin concentration was measured with radioimmunoassay(RIA) kit.Surface gastric pacing at 1.1-1.2 times the intrinsicslow-wave frequency and a superimposed series of highfrequency pulses (10-30 Hz) was performed for 45 rnin dailyfor a month in conscious dogs.RESULTS:After surgery,GEt_(1/2) in dogs undergone truncalvagotomy was increased significantly from 56.35±2.99 minto 79.42±1.91 rain (P<0.001),but surface gastric pacingmarkedly accelerated gastric emptying and significantlydecreased GEt_(1/2) to 64.94+1.75 min (P<0.001) in animalsundergone vagotomy.There was a significant increase ofplasma level of motilin at the phase of IMCⅢ(interdigestivemyoelectrical complex,IMCⅢ) in the dogs undergone bilateraltruncal vagotomy (baseline vsvagotomy,184.29±9.81 pg/mlvs 242.09±17.22 pg/ml;P<0.01).But plasma motilinconcentration (212.55±11.20 pg/ml;P<0.02) was decreasedsignificantly after a long-term treatment with gastric pacing.Before gastric pacing,GEt_(1/2) and plasma motilin concentrationof the dogs undergone vagotomy showed a positivecorrelation (r=0.867,P<0.01),but after a long-term gastricpacing,GEt_(1/2) and motilin level showed a negative correlation(r=-0.733,P<0.04).CONCLUSION:Surface gastric pacing with optimal pacingparameters can improve gastric emptying parameters andsignificantly accelerate gastric emptying and can resumeor alter motor function in a canine model of motilitydisorders.Gastric emptying is correlated well with plasmamotilin level before and after pacing,which suggests that motilin can modulate the mechanism of gastric pacing byaltering gastric motility. AIM: To investigate the effects of gastric pacing on gastrice pumping and plasma motilin level in a canine model of gastric motility disorders and the correlation between gas pumping and plasma motilin level. METHODS: Ten healthy Mongrel dogs were divided into: experimental group of six dogs and control group of four dogs. A model of gastric motility disorders was established in the experimental group undergone truncal vagotomycombined with injection of glucagon. Genetic half-emptying time (GEt_ (1/2)) was monitored with single photon emission computerized tomography (SPECT), and the half- solid testmeal was labeled with an isotope- (99m) mTc sulfur colloid. Plasmotilin concentration was measured with radioimmunoassay (RIA) kit. Surface gas pacing at 1.1-1.2 times the intrinsics low-wave frequency and a superimposed series of high frequency pulses (10-30 Hz) was performed for 45 rnin daily for a month in conscious dogs. RESULTS: After surgery, GEt_ (1/2) in dogs undergone truncalvagotomy increased significantly from 56.35 ± 2.99 minto 79.42 ± 1.91 rain (P <0.001), but surface gastric pacingmarkedly accelerated gastric emptying and significantly decreased GEt 1/2 (1/2) to 64.94 + 1.75 min (P <0.001) in animalsundergone vagotomy.There was a significant increase ofplasma level of motilin at the phase of IMCⅢ (IMCⅢ) in the dogs undergone bilateraltruncal vagotomy (184.29 ± 9.81 pg / ml vs 242.09 ± 17.22 pg / ml; P <0.01) .But plasma motilinconcentration (212.55 ± 11.20 (1/2) and plasma motilin concentration of the dogs undergone vagotomy showed a positivecorrelation (r = 0.867, P <0.01). Pg / ml; P <0.02) was decreased significantly after a long-term treatment with gastric pacing. , but after a long-term gastricpacing, GEt_ (1/2) and motilin level showed a negative correlation (r = -0.733, P <0.04) .CONCLUSION: Surface gastric pacing with optimal pacing parameters can improve gastric emptying parameters and sulfidative gastric emptying ing andcan resumeor alter motor function in a canine model of motility disorders. Gastric emptying is correlated well with plasma motilin level before and after pacing, which suggests that motilin can modulate the mechanism of gastric pacing byaltering gastric motility.