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目的:研究哺乳动物雷帕霉素靶蛋白(mTOR)、真核细胞始动因子4E结合蛋白l(4EBP1)在喉鳞状细胞癌组织中的表达及相关性。方法:采用免疫组织化学方法检测mTOR、4EBP1在77例喉癌组织和18例癌旁组织中的表达,分析其表达与常见临床病理因素之间的关系。结果:mTOR、4EBP1在喉癌中的阳性表达率分别为54.5%、48.1%,均高于癌旁组织中的表达(P<0.05)。mTOR、4EBP1的阳性表达与淋巴结转移及组织病理学分级有显著相关性(P<0.05),而与临床分期无相关性(P>0.05)。mTOR和4EBP1在喉癌中的表达呈正相关(P<0.05)。结论:①mTOR和4EBP1的高表达与喉癌的发病、侵袭、转移有关;②mTOR和4EBP1在喉癌组织中的阳性率呈正相关,联合检测对喉癌的治疗和预后判断具有重要临床意义。
Objective: To study the expression and correlation of mammalian target of rapamycin (mTOR) and eukaryotic initiation factor 4E binding protein 1 (4EBP1) in laryngeal squamous cell carcinoma. Methods: The expressions of mTOR and 4EBP1 were detected by immunohistochemistry in 77 cases of laryngeal carcinoma and 18 cases of paracancerous tissues. The relationship between mTOR and 4 clinicopathological parameters was analyzed. Results: The positive rates of mTOR and 4EBP1 in laryngeal carcinoma were 54.5% and 48.1%, respectively, which were higher than those in paracancerous tissues (P <0.05). The positive expressions of mTOR and 4EBP1 were significantly correlated with lymph node metastasis and histopathological grade (P <0.05), but not with clinical stage (P> 0.05). The expression of mTOR and 4EBP1 in laryngeal carcinoma was positively correlated (P <0.05). CONCLUSION: ① The overexpression of mTOR and 4EBP1 is associated with the pathogenesis, invasion and metastasis of laryngeal carcinoma. ② The positive rates of mTOR and 4EBP1 in laryngeal carcinoma are positively correlated. The combined detection has important clinical significance for the treatment and prognosis of laryngeal carcinoma.