吲哚及其衍生物广泛存在于天然产物、药物及其他功能分子中.近年来,惰性键活化成为杂环合成的研究主流.已知的碳氢键活化合成吲哚的方法主要利用导向基定位实现过渡金属活化并与炔烃环化.然而,使用的静态导向基残留于目标分子中,大大局限了产物的用途.北京大学深圳研究生院黄沔课题组首次设计了具有非常广泛化学衍牛 Indole and its derivatives are widely found in natural products, drugs and other functional molecules.In recent years, the activation of inert bond has become the mainstream of heterocyclic synthesis.It is known that the method of activating carbon bond to synthesize indole mainly utilizes the orientation of the guide To achieve transition metal activation and alkyne cyclization.However, the use of static guide residues in the target molecule, greatly limiting the use of the product.Peking University Shenzhen Graduate School Huang Xuan task force for the first time with a very wide range of chemical derivative cattle