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目的探讨低出生体重早产儿闪光刺激视觉诱发电位(FVEP)变化及相关影响因素。方法对2007年11月至2008年12月本院住院、围产期有合并症的低出生体重儿和极低出生体重儿进行FVEP检测,与无合并症的低出生体重早产儿(低体重对照组)及健康足月儿进行对比。对有合并症早产儿的围产因素进行Logistic回归分析,筛选出与主波P1异常相关的影响因素,列出回归方程。结果极低体重儿组N1、P1、N2波潜伏期均值分别为(181.4±26.7)ms、(217.3±26.5)ms和(249.2±26.5)ms,低体重儿组分别为(177.6±18.7)ms、(217.6±23.2)ms和(250.1±20.4)ms,低体重对照组分别为(158.9±32.1)ms、(199.9±13.3)ms和(232.9±16.7)ms,足月儿组分别为(159.5±18.3)ms、(200.3±13.9)ms和(231.6±15.7)ms。极低体重儿组和低体重儿组各波潜伏期均较足月儿组长,主波P1波潜伏期较足月儿和低体重对照组长,差异有统计学意义(P均<0.001)。极低体重儿组、低体重儿组P1波异常率较低体重对照组高(75.6%、58.4%比5.0%,P<0.001)。114例有合并症早产儿主波异常的主要相关影响因素是脑损伤(OR=3.955)。结论围产期有合并症的低体重早产儿和极低出生体重儿FVEP检查异常率较高;FVEP异常改变与脑损伤病变关系密切。
Objective To investigate the changes of flash-induced visual evoked potentials (FVEP) and its related factors in preterm infants with low birth weight. Methods FVEP was detected in hospitalized and perinatal patients with complications of low birth weight and very low birth weight during November 2007 to December 2008 in our hospital. Compared with those without complications, low birth weight preterm infants (low body weight control Group) and healthy term infants were compared. Logistic regression analysis of perinatal factors in patients with comorbid preterm birth, screening out the influencing factors associated with the abnormal wave of the main wave P1, the regression equation is listed. Results The mean latency of N1, P1 and N2 in the low birth weight infants was (181.4 ± 26.7) ms, (217.3 ± 26.5) ms and (249.2 ± 26.5) ms respectively, while the low body weight infants were (177.6 ± 18.7) ms, (217.6 ± 23.2) ms and (250.1 ± 20.4) ms, and the low-body weight control group was (158.9 ± 32.1) ms and (199.9 ± 13.3) ms and (232.9 ± 16.7) ms respectively 18.3) ms, (200.3 ± 13.9) ms and (231.6 ± 15.7) ms. The latent period of each wave in the children with very low birth weight and low birth weight was longer than that of the full-length children. The latency of the main wave P1 wave was longer than that of the full-moon and low-weight control group (P <0.001). In the children with very low birth weight and low birth weight, the abnormalities of P1 wave were lower (75.6%, 58.4% vs. 5.0%, P <0.001) in the control group. The main influencing factor of 114 patients with comorbid premature infants was brain injury (OR = 3.955). Conclusion FVEP abnormalities in preterm infants with very low birth weight and those with very low birth weight are higher in perinatal period. The abnormal changes of FVEP are closely related to the lesions of brain injury.