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目的:研究番茄红素对酒精所致小鼠急性化学性肝损伤的保护作用。方法:雄性昆明种小鼠60只,随机分为正常对照组、急性酒精肝损伤模型组、联苯双酯阳性对照组(15mg/kg)以及番茄红素低、中、高剂量组(10、15、20mg/kg)共6组。测定并比较各组小鼠肝脏系数,血清中丙氨酸氨基转移酶(ALT)、大门冬氨酸氨基转移酶(AST)、超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-Px)活性与丙二醛(MDA)含量;测定肝组织中SOD、GSH-Px活性、MDA含量以及组织病理系数。结果:番茄红素各剂量组均能升高急性酒精肝损伤小鼠血清与肝组织SOD、GSH-Px活性(P<0.01),降低血清ALT、AST活性(P<0.01)和血清与肝组织MDA含量(P<0.01),并能不同程度地改善肝脏病理组织损伤。结论:番茄红素对酒精所致急性肝损伤具有预防性保护作用。
Objective: To study the protective effect of lycopene on alcohol-induced acute chemical liver injury in mice. Methods: Sixty male Kunming mice were randomly divided into normal control group, acute alcohol injury model group, biphenylamine positive control group (15mg / kg) and low, medium and high dosage of lycopene group (10, 15, 20 mg / kg) for a total of 6 groups. The hepatic coefficient, ALT, AST, SOD and GSH-Px in mice were measured and compared. (GSH-Px) activity and malondialdehyde (MDA) content. The activities of SOD, GSH-Px, MDA and histopathological parameters in liver tissue were determined. Results: Lycopene could elevate the activity of SOD, GSH-Px in serum and liver tissue (P <0.01), decrease the activity of ALT and AST (P <0.01) and the level of serum and liver tissue MDA content (P <0.01), and to varying degrees to improve the liver pathological tissue injury. Conclusions: Lycopene has a protective effect against acute liver injury induced by alcohol.