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目的探讨哨兵淋巴结活检(SLNB)预测结肠癌患者淋巴结转移状态的重要性和可行性。方法使用亚甲蓝对42例结肠癌患者进行SLNB,随后行标准的结肠癌根治术。哨兵淋巴结阴性患者进行连续切片病理检测。结果SL-NB成功率为80.95%,敏感度为97.06%,特异度为100%,预测淋巴结转移状态率为95.45%,假阴性率为4.55%。结论利用亚甲蓝淋巴定位方法进行的SLNB可以准确预测淋巴结转移状态,SLN连续切片、HE染色检测有助于提高SLNB的敏感性。
Objective To investigate the significance and feasibility of sentinel lymph node biopsy (SLNB) in predicting lymph node metastasis in patients with colon cancer. Methods SLNB was performed on 42 patients with colon cancer using methylene blue followed by a standard radical resection of colon cancer. Sentinel lymph node-negative patients with serial sections pathological examination. Results The success rate of SL-NB was 80.95%, the sensitivity was 97.06% and the specificity was 100%. The predictive rate of lymph node metastasis was 95.45% and the false-negative rate was 4.55%. Conclusion SLNB using methylene blue lymphatic mapping method can accurately predict the status of lymph node metastasis, SLN serial sections, HE staining test can help improve the sensitivity of SLNB.